37°C
+37.0 °C — ischaemia begins
Persist Bio · the molecule company for cryopreservation

It starts at 37°C.

The body runs warm. The moment an organ leaves it, a countdown begins — and today, nothing can pause it. This is a descent through the temperatures that decide whether an organ lives or is lost.
Scroll to begin the descent
Researcher working beside cryopreservation laboratory equipment
Real research · the countdown

The moment an organ leaves the body, the countdown begins.

0.0 °C — water turns to ice

At 0°C, water becomes a weapon.

The body is roughly 60% water. Freeze it and sharp ice crystals form, tearing cell membranes apart. This is why organs cannot simply be frozen — the cold that should preserve them destroys them.

−80.0 °C — where ice growth is greatest
The wall we hit today

The old fix holds back the ice — but can be toxic to the tissue.

CPAsThe 60-year standardSince the 1960s
Old CPAs block ice only at concentrations that can be toxic to the very tissue they protect.
01Toxic effectsLower viability
Impairs functional recovery on revival.
02High concentrationCure = cause
The dose needed to protect begins to harm.
03Whole organsNo organ banking
Concentration gradients make large organs unreachable.
Researcher conducting laboratory work at a cryopreservation workstation
Real research · validation

From hypothesis to laboratory validation.

−130.0 °C — the glass transition

At −130°C, water can become glass — if the molecule is right.

Conventional — ice
Crystals form · cells rupture & die from toxicity
Vitrification — glass
No crystals · structure intact
We design the molecule, not the machine AI-guided platform & discovery Non-toxic CPAs
Persist Bio team members beside full-scale cryogenic laboratory equipment
Real infrastructure · the opportunity

Own the molecule, and you own the layer all of preservation depends on.

Below −130.0 °C — cryogenic storage

Below −130°C: toward an organ bank.

If organ preservation can one day be made reversible, transplantation could stop being a race — organs stored, matched globally and used when needed. A research goal Persist Bio is working toward, not a current capability.
Long-term
Storage goal
Global
Matching pool
Lower loss
Less time pressure
Nils Regge · FounderEmil Kendziorra, MD · FounderAlexander Murray, PhD · Cryobiologist